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Weight Loss Supplement Guide

Last Updated February 12, 2024Our curated list of the most popular weight loss supplements was designed to be your go-to source for expert guidance in choosing the right supplement to shed those extra pounds based on your individual needs. We cut through the noise to bring you the best, science-backed, all-natural weight loss supplements for your weight loss and health and wellness journey. We understand how overwhelming it can be to navigate through all of the options out there for kickstarting your weight loss plan. That said, we get straight to the point, no fluff, just clear insights to help you supercharge your efforts. Whether you're looking to rev up your metabolism or curb those cravings - we've got you covered! We continuously evaluate the weight loss supplement industry to ensure that our list only includes supplements that have excellent, verified buyer reviews and video testimonials that demonstrate actual weight loss, as well as having a high re-buy rate and a low return/refund rate. *Please note, the brands/manufacturers of the weight loss supplements listed on this page strictly prohibit the sale of their products on retail marketplaces such as Amazon and eBay by anyone except the parent company. If you see any of these supplements on a retail marketplace, they are potentially (in all honesty, most likely) fake. The product links on our list connect you directly to the manufacturer for your safety. If you make a purchase from one of our links, we may receive a small commission; however, we do not include or exclude products based on whether or not the vendor is a partner of Better YOU Supps.


LeanBliss is a doctor-formulated, stimulant-free weight loss supplement that has been shown to lower blood sugar and melt off fat faster than keto. The company reports that users are, in fact, melting off fat up to 450% faster than with the keto diet. The creation of LeanBliss was inspired by the need and demand for a safer alternative to Ozempic, the diabetes drug that resulted in massive weight loss among celebrities and influencers.

The herbal proprietary blend includes ceylon cinnamon bark, corosolic acid (from banaba leaf extract), saffron bulb extract, fucoxanthin (from laminaria japonica), citrus sinensis, fucoidan (from laminaria japonica), kudzu flower extract, oleuropein (from olive leaf extract), berberine, and xylitol. All of the ingredients have been proven to be safe in clinical trials, and best of all, it tastes like chocolate!

LeanBliss for Weight Loss, Fast Metabolism & Energy
BioVanish for Weight Loss - Get Keto-Skinny without Eating Keto


WellMe BioVanish is a cocoa-flavored drink mix designed to accelerate weight loss results. By taking BioVanish daily, you can enjoy the effects of the keto diet without actually being on the keto diet.

BioVanish’s unique formula combines three clinically-proven nutrients that support your body’s production of Beta-hydroxybutyrate (BHB) to bring about fast results. BHB signals your body to use stored fat for energy instead of glucose, which helps you lose weight very quickly and provides a clean energy source for your brain to keep you sharp and energized.

BioVanish also includes healthy fat from coconut extract, L-Theanine, and B-vitamins that work together to help you hit your weight loss and fitness goals and get the body you’ve always wanted.


Lean for Good LeanBiome is a 9-strain probiotic supplement containing 20 billion CFUs (colony-forming units). This unique blend of gut-supporting ingredients is scientifically shown to support your weight loss and fitness goals by rebalancing the gut microbiome to reduce fat storage.

The LeanBiome powerhouse probiotic blend improves overall gut health. The key probiotics that rebalance your microbiome include lactobacillus gasseri, lactobacillus rhamnosus, and lactobacillus fermentum. It also contains Greenselect Phytosome®, a caffeine-free green tea extract formulated with absorption-boosting technology.

This revolutionary combination swiftly tackles the root cause of belly fat and mysterious weight gain by restoring balance to your gut microbiome, setting the stage for rapid transformation.

LeanBiome for Weight Loss
SeroLean for Weight Loss and Weight Management


SeroLean is a 100% science-backed natural alternative to Ozempic. This cutting-edge weight loss supplement has garnered widespread acclaim for its innovative approach to addressing obesity. What sets SeroLean apart from conventional supplements is its primary mechanism of action – the modulation of serotonin levels in the brain. Serotonin, often referred to as the “feel-good” neurotransmitter, plays a pivotal role in regulating mood, appetite, and sleep.

The success of the thousands of men and women who have already used SeroLean is attributed to the meticulously selected ingredients that make up its formulation. Each ingredient plays a crucial role in the overall mechanism of serotonin modulation, contributing to the supplement’s effectiveness for weight loss and safety.


Puravive is known as "Hollywood's Exotic Secret for Healthy Weight Loss." It is one of the only supplements available designed to target and optimize low brown adipose tissue (BAT) levels, also known as brown fat.

Brown fat is responsible for producing heat to warm the blood in your body. You actually start to burn fat right before you start to shiver because the fat activates (turns on) in cold temperatures. It produces heat by breaking down blood sugar (glucose) and molecules of fat. This process (thermogenesis) creates heat to help you maintain your body temperature. Even though brown fat is present in your body at a lower percentage, it can burn up to 300 times more than any other cell in your body.

Puravive's formula revs up metabolism, boosts energy, and encourages healthy sleep cycles by targeting and optimizing BAT levels.

Puravive for Weight Loss
MenoRescue for Weight Loss: Escape the Menopause Rollercoaster


WellMe MenoRescue offers a unique approach to menopause, addressing what growing research now suggests is the biggest factor in menopausal misery: unhealthy cortisol levels.

MenoRescue's exclusive ingredient blend supports "the change" in two distinct but complementary ways. First, by promoting healthy cortisol levels to encourage estrogen and progesterone balance; and second, by gently supporting the body's production of those hormones.

By targeting menopausal misery from both angles, MenoRescue helps promote a healthy body temperature, faster fat burning and weight loss, all-day energy, restful sleep, youthful brain function, a balanced mood, flexible joints, a healthy heart, and a happy, care-free menopause!

Liv Pure

Liv Pure is an effective weight loss supplement that entered the market following a significant breakthrough in scientific discoveries. In 2023, compromised liver function was identified as a common factor in overweight individuals.

Liv Pure addresses this with its proprietary Liver Purification and Fat-Burning Complex, optimizing liver function for enhanced metabolism, calorie burning, and fat loss. Users experience increased energy, healthier skin, improved sleep, reduced hunger, clearer thinking, and overall improved health.

Their natural approach is powered by plant ingredients and is non-GMO, soy and dairy-free, easy to swallow, and non-habit forming. Liv Pure is designed to transform your weight loss journey with its revolution in optimal liver function and effective fat burning.

Live Pure for Weight Loss and Liver Health
Sumatra Slim Belly Tonic for Weight Loss, Energy and Vitality

Sumatra Slim Belly Tonic

Sumatra Slim Belly Tonic is a powerful natural formula that offers comprehensive support for healthy weight loss with lasting results. Its proprietary blend of 8 proven natural ingredients targets potential causes of unexplained weight gain, such as blue light exposure from devices and lack of N-REM sleep.

The Sumatra Slim Belly Tonic supplement is extremely popular on TikTok. Users claim to experience a transformation in body, mind, and overall health with benefits like increased energy, clearer thoughts, a healthy inflammatory response, improved sleep quality, and enhanced skin appearance.


Puradrop gummies help you lose weight and keep it off. They are infused with superfoods that support metabolism, fat burn, and weight loss. Customers who have reviewed Puradrop Gummies rave about how delicious and easy to take they are.

The key ingredient in Puradrop is Vinagre De Sidra De Manza, which is backed by powerful clinical studies. They ensure that everything you're taking is scientifically proven to help you lose weight fast, and they have compiled their clinical studies and provide them on their site so you can see the scientific proof of weight loss using unbiased, methodical testing.


The key benefits of Puradrop are that it accelerates fat burning by encouraging your body to use fat for fuel, suppresses appetite, ramps up metabolism, and promotes sustained weight loss.

Puradrop for Weight Loss and Healthy Detoxing

*Buying direct is the only way to ensure the authenticity and freshness of the supplements you put into your body. We are an authorized affiliate for all of the brands on this site and we earn a small commission when you purchase products from our links.

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